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藥物靶點(diǎn)重組兔單克隆抗體
締碼生物創(chuàng)新性的兔重組單克隆抗體平臺，聚焦腫瘤免疫靶點(diǎn)，使用功能活性充分驗(yàn)證的重組蛋白作為抗原免疫兔子，直接從陽性兔B細(xì)胞中克隆IgG，重組表達(dá)進(jìn)行流式驗(yàn)證。這一技術(shù)不僅大大縮短了研發(fā)的時(shí)間，也讓我們能夠直接獲得IgG的基因序列信息，而無需擔(dān)心雜交瘤細(xì)胞丟失。
DIMA mAbs優(yōu)勢
現(xiàn)貨供應(yīng)，覆蓋多個熱門腫瘤靶點(diǎn)：
已成功開發(fā)出5000+兔單抗產(chǎn)品，覆蓋500余種靶點(diǎn)。
應(yīng)用范圍廣泛：
產(chǎn)品均經(jīng)過ELISA或流式驗(yàn)證，還可開發(fā)WB、IHC、IF、熒光標(biāo)記等應(yīng)用。
高特異性、高親和力：
兔抗體基因庫具有更高多樣性，更高親和力，表位覆蓋更廣。
多種抗體類型：
兔單抗、人兔嵌合抗體、人源化抗體等。
成藥性高：
締碼基于單B細(xì)胞技術(shù)的兔單抗發(fā)現(xiàn)平臺開發(fā)出來的抗體成藥性高。
高性價(jià)比，定制靈活：
可提供多標(biāo)簽、多種屬及大規(guī)格包裝定制。
B細(xì)胞種子庫高效篩選兔單抗
締碼生物擁有獨(dú)創(chuàng)的DIMA mAbs重組單克隆抗體開發(fā)平臺，可以在完成動物免疫后直接從外周血中獲取陽性B細(xì)胞并克隆抗體基因序列。從單只免疫動物中我們可以得到上萬個靶點(diǎn)結(jié)合陽性B細(xì)胞克隆，從中能夠更為高效的篩選出具有高特異性、高親和力重組單克隆抗體。
熱門抗體靶點(diǎn)
| 2B4 | 4-1BB | 4-1BB-L | SIRPα |
| B7-H3 | BCMA | CD123 | CD48 |
| CD138 | CD22 | CD27 | GITR Ligand |
| CD28 | CD38 | CD47 | CS1 |
| GPRC5D | CTLA-4 | MSLN | TROP2 |
| GITR | TIM3 | B7-2 | PSCA |
| NKp30 | BTN3A1 | DNAM1 | B7-H2 |
| CD40 |
驗(yàn)證數(shù)據(jù)展示
A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (DME100008). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DME100008 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.
Left: Western blot analysis of CD38 protein using Anti-CD38 antibody (Cat. DME100027) at 1:1000 dilution.
Right: Western blot analysis of CD48 protein using Anti-CD48 antibody (SKU# DME100043) at 1/1000 dilution.
Anti-CD27 antibody(DM59), Rabbit mAb (DME100059) at 10μg/ml staining CD27 in Raji cells by IHC (SKU# DME100059);B. DME100059 at 10μg/ml staining CD27 in human tonsil tissue by IHC (SKU# DME100059)
A: The scheme of Anti-BCMA BiTE molecule (Cat. DMB100003). B: Tumor cell killing assay.?
單克隆抗體
Monoclonal Antibodies
SKU: DMC101038 Target: CD98
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101034 Target: BTN3A2
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101033 Target: CD79B
Application: Flow Cyt; WB
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101040 Target: EGFRVIII
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101039 Target: CLEC4C
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101037 Target: TNFRSF1B
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101036 Target: FGF19
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101035 Target: CGRP
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DME101007 Target: MMAE
Application: ELISA
Price: 10μg ￥500.00; 50μg ￥1500.00 ; 100μg ￥3000.00 ; 500μg ￥9000.00
Monoclonal Antibodies
SKU: DME101006 Target: MMAE
Application: ELISA
Price: 10μg ￥500.00; 50μg ￥1500.00 ; 100μg ￥3000.00 ; 500μg ￥9000.00
Monoclonal Antibodies
SKU: DME101005 Target: MMAE
Application: ELISA
Price: 10μg ￥500.00; 50μg ￥1500.00 ; 100μg ￥3000.00 ; 500μg ￥9000.00
Monoclonal Antibodies
SKU: DME101004 Target: MMAE
Application: ELISA
Price: 10μg ￥500.00; 50μg ￥1500.00 ; 100μg ￥3000.00 ; 500μg ￥9000.00
Monoclonal Antibodies
SKU: DME101003 Target: MMAE
Application: ELISA
Price: 10μg ￥500.00; 50μg ￥1500.00 ; 100μg ￥3000.00 ; 500μg ￥9000.00
Monoclonal Antibodies
SKU: DMC101005 Target: CD6
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101004 Target: GPC1
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101002 Target: APP
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100721 Target: IGF-1R
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100488 Target: LIV-1
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
新的
Monoclonal Antibodies
SKU: DMC101006 Target: IL1A
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101003 Target: CCR5
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC101001 Target: GIPR
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100720 Target: ENPP3
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100688 Target: ASGR1
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100687 Target: CXADR
Application: Flow Cyt; WB; IHC
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100685 Target: CEACAM6
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100683 Target: TENM4
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100682 Target: CD166
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100681 Target: CXCR2
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100680 Target: CXCR4
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100679 Target: CXCR5
Application: Flow Cyt; IHC
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100675 Target: CDH6
Application: Flow Cyt; WB
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Monoclonal Antibodies
SKU: DMC100674 Target: CD74
Application: Flow Cyt
Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
