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藥物靶點重組兔單克隆抗體
締碼生物創(chuàng)新性的兔重組單克隆抗體平臺，聚焦腫瘤免疫靶點，使用功能活性充分驗證的重組蛋白作為抗原免疫兔子，直接從陽性兔B細胞中克隆IgG，重組表達進行流式驗證。這一技術不僅大大縮短了研發(fā)的時間，也讓我們能夠直接獲得IgG的基因序列信息，而無需擔心雜交瘤細胞丟失。
DIMA mAbs優(yōu)勢
現(xiàn)貨供應，覆蓋多個熱門腫瘤靶點：
已成功開發(fā)出5000+兔單抗產品，覆蓋500余種靶點。
應用范圍廣泛：
產品均經過ELISA或流式驗證，還可開發(fā)WB、IHC、IF、熒光標記等應用。
高特異性、高親和力：
兔抗體基因庫具有更高多樣性，更高親和力，表位覆蓋更廣。
多種抗體類型：
兔單抗、人兔嵌合抗體、人源化抗體等。
成藥性高：
締碼基于單B細胞技術的兔單抗發(fā)現(xiàn)平臺開發(fā)出來的抗體成藥性高。
高性價比，定制靈活：
可提供多標簽、多種屬及大規(guī)格包裝定制。
B細胞種子庫高效篩選兔單抗
締碼生物擁有獨創(chuàng)的DIMA mAbs重組單克隆抗體開發(fā)平臺，可以在完成動物免疫后直接從外周血中獲取陽性B細胞并克隆抗體基因序列。從單只免疫動物中我們可以得到上萬個靶點結合陽性B細胞克隆，從中能夠更為高效的篩選出具有高特異性、高親和力重組單克隆抗體。
熱門抗體靶點
| 2B4 | 4-1BB | 4-1BB-L | SIRPα |
| B7-H3 | BCMA | CD123 | CD48 |
| CD138 | CD22 | CD27 | GITR Ligand |
| CD28 | CD38 | CD47 | CS1 |
| GPRC5D | CTLA-4 | MSLN | TROP2 |
| GITR | TIM3 | B7-2 | PSCA |
| NKp30 | BTN3A1 | DNAM1 | B7-H2 |
| CD40 |
驗證數(shù)據(jù)展示
A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (DME100008). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DME100008 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.
Left: Western blot analysis of CD38 protein using Anti-CD38 antibody (Cat. DME100027) at 1:1000 dilution.
Right: Western blot analysis of CD48 protein using Anti-CD48 antibody (SKU# DME100043) at 1/1000 dilution.
Anti-CD27 antibody(DM59), Rabbit mAb (DME100059) at 10μg/ml staining CD27 in Raji cells by IHC (SKU# DME100059);B. DME100059 at 10μg/ml staining CD27 in human tonsil tissue by IHC (SKU# DME100059)
A: The scheme of Anti-BCMA BiTE molecule (Cat. DMB100003). B: Tumor cell killing assay.?
單克隆抗體
Monoclonal Antibodies
SKU: DMC101041P Target: CDH3
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-TNFRSF1B antibody(8C4); IgG1 Chimeric mAb
SKU: DMC101037P Target: TNFRSF1B
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC101036P Target: FGF19
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC101035P Target: CGRP
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC101034P Target: BTN3A2
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC101004P Target: GPC1
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-LIV-1 antibody(DMC488); IgG1 Chimeric mAb
SKU: DMC100488P Target: LIV-1
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-ASGR1 antibody(DMC688), IgG1 Chimeric mAb
SKU: DMC100688P Target: ASGR1
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-CXADR antibody(DMC687), IgG1 Chimeric mAb
SKU: DMC100687P Target: CXADR
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-TENM4 antibody(DMC683); IgG1 Chimeric mAb
SKU: DMC100683P Target: TENM4
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-CD166 antibody(DMC682), IgG1 Chimeric mAb
SKU: DMC100682P Target: CD166
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-CXCR2 antibody(DMC681); IgG1 Chimeric mAb
SKU: DMC100681P Target: CXCR2
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-CXCR4 antibody(DMC680), IgG1 Chimeric mAb
SKU: DMC100680P Target: CXCR4
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-CXCR5 antibody(DMC679), IgG1 Chimeric mAb
SKU: DMC100679P Target: CXCR5
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC100675P Target: CDH6
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-CRTAM antibody(DMC673); IgG1 Chimeric mAb
SKU: DMC100673P Target: CRTAM
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-HBEGF antibody(DMC500); IgG1 Chimeric mAb
SKU: DMC100500P Target: HBEGF
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-CXCL1 antibody(DMC499); IgG1 Chimeric mAb
SKU: DMC100499P Target: CXCL1
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC100498P Target: GDNF
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-GPA33 antibody(DMC497); IgG1 Chimeric mAb
SKU: DMC100497P Target: GPA33
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC100495P Target: YAP1
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-CD32a antibody(DMC494); IgG1 Chimeric mAb
SKU: DMC100494P Target: CD32a
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC100486P Target: CD23
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC100484P Target: CDH1
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-CHI3L1 antibody(DMC483); IgG1 Chimeric mAb
SKU: DMC100483P Target: CHI3L1
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-GPR77 antibody(DMC482); IgG1 Chimeric mAb
SKU: DMC100482P Target: C5AR2
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-ADGRE1 antibody(DMC481); IgG1 Chimeric mAb
SKU: DMC100481P Target: ADGRE1
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC100480P Target: DDR1
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-APCDD1 antibody(DMC479); IgG1 Chimeric mAb
SKU: DMC100479P Target: APCDD1
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-GPR87 antibody(DMC478); IgG1 Chimeric mAb
SKU: DMC100478P Target: GPR87
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
SKU: DMC100477P Target: CCR6
Application: Flow Cyt
Price: 100 test ￥3880.00
Monoclonal Antibodies
PE-conjugated Anti-CD164 antibody(DMC476); IgG1 Chimeric mAb
SKU: DMC100476P Target: CD164
Application: Flow Cyt
Price: 100 test ￥3880.00
